Post-Traumatic Stress Disorder is a psychiatric disorder which can develop following exposure to a traumatic event (e.g., combat exposure, terrorist attack, car crash), and is characterized by altered fear-related learning and extinction related to glutamate dysfunction in trauma-related brain regions.
Hearing Loss may develop slowly over many years or set in acutely (e.g. following some noise or head trauma). It may be either due to insufficient sound conduction from the outer to the inner ear or much more frequently to damage to the hair cells and neurons in the cochlea or to the auditory nerve.
PRAGMA Therapeutics develops innovative medicines through modulation of the
metabotropic glutamate receptor subtype 7 (mGlu7) for the treatment of these two severe debilitating conditions affecting both civilian and military populations.
